Ryanair is to launch its first flights from Exeter next April.
The budget airline will offer flights to Malaga, Malta and Naples throughout the summer.
It will offer a total of six flights a week, flying up to 80,000 passengers from the Devon airport.
Ryanair spokesman Robin Kiely said: "We're pleased to announce Ryanair's low fares have arrived at Exeter, our newest airport and 21st in the UK.
"Our three new routes to Malaga, Malta and Naples start in summer 2019, each operating twice weekly, ensuring customers in the Devon region can book low fare flights to the sun."
Exeter Airport MD Matt Roach said: "This is a significant vote of confidence in the continued growth of Exeter Airport and we are delighted to be welcoming Ryanair for the very first time. These routes are popular destinations and offer customers even more choice and greater connectivity from their local airport."
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